Isolation and Structural Elucidation of a Novel Heptaoxygenated Xanthone from Securidaca longepedunculata Fresen. with Potential Antimicrobial Properties

Abstract

In the search for novel antimicrobial agents to combat drug-resistant pathogens, we isolated and 
characterized a new heptaoxygenated xanthone, 1,6-dihydroxy-2,3,5,7,8-pentamethoxyxanthone (1), from 
Securidaca longepedunculata. The structure was elucidated using comprehensive spectroscopic techniques 
(IR, UV, EIMS, and 1D/2D NMR), revealing a unique substitution pattern. Additionally, the known 
benzophenone (4-methoxybenzo[1,3]dioxol-5-yl)-phenylmethanone (2) was identified. Compound 1’s 
structural features suggest potential antimicrobial activity, warranting further biological evaluation. This 
study underscores the plant’s role as a source of bioactive xanthones for addressing antimicrobial resistance.