Evaluation of Ibuprofen Tablets Obtained from Prepared Microcrystalline Cellulose from Gompherena serrata (Batchelors Button) as Pharmaceutical Disintegrant

Abstract

Acid hydrolysis of microcrystalline cellulose can improve its physicochemical properties such as solubility, swelling capacity and gelatinization which are very important for pharmaceutical application. The objectives of this study were to formulate Ibuprofen tablets using different microcrystalline cellulose such as prepared microcrystalline cellulose (PMCC) and commercial microcrystalline cellulose (CMCC) and to evaluate their efficacy as pharmaceutical excipient. Six batches of Ibuprofen 200 mg tablets were prepared by direct compression technique using cellulose as binders and disintegrants, with total of 100 tablets per batch. The tablets were produced using tableting machine and then subjected to routine pharmaceutical quality evaluations. All the formulated samples passed the uniformity of weight test, hardness test, disintegration test, and friability test. All the tablets formed using the prepared MCC obtained from Gompherena serrata Fiber were good and acceptable as none had a surface defect with all the pharmacopoeia test carried out on the tablets in compliance BP, 2012. As such, it can be concluded that MCC can be extracted from Gompherena serrata fiber; which can be used to produce ibuprofen tablets.