Comparative Analysis of the Level of Metformin Hydrochloride in Different Tablets Brands Sold in Kano Metropolis, Nigeria

Abstract

Metformin hydrochloride, a commonly prescribed medication for type 2 diabetes management which 
works by helping to restore the body's response to insulin. It decreases the amount of blood sugar that the 
liver produces and the intestines or stomach absorb. Manufacturing processes may lead to differences in 
the concentration of the active pharmaceutical ingredient (API) and quality parameters among different 
brands. Ensuring the quality and consistency of these brands is crucial for patient safety and treatment 
efficacy. The study aimed to assess and compare the identity and quality of different brands of Metformin 
hydrochloride tablets marketed in Kano, Nigeria using Ultra-Visible (UV) and Fourier transform infrared 
(FTIR) spectrophotometer among other methods. Uniformity of weight test and identification test were 
also conducted on the sample. The UV result showed that all samples pass the assay test with percentage 
purity ranging from 96.99 to 99.15 %. Similarly, the brand samples pass identification test with red-orange 
colour indication. The difference in average weight has 830.8g as the highest and 525.8g as the lowest. 
The vibrational band assignments of Metformin hydrochloride were made using FTIR measurements; and 
provided satisfactory vibrational band assignments of Metformin hydrochloride that gave further accuracy 
and reliability of the analysis. The results of the research indicated that the manufacturing processes of the 
assessed Metformin hydrochloride tablets adhere to specified quality standards, offering valuable 
Metformin hydrochloride brands to the market from the methods used.